Chemical profiling and cytotoxic activity of aqueous extract of Veronica peduncularis M.Bieb.: A chemotaxonomical approach

Background and Aims: Genus Veronica (Plantaginaceae) is represented by 79 species in Turkish flora, 26 of which are endemic. have a variety uses including diuretic, anticancer, rheumatic pains, wounds, respiratory problems. According to phytochemical studies, contain predominantly iridoid glucosides with some phenylethanoid flavonoid glycosides. Methods: The aqueous extract peduncularis M.Bieb. was tested for its cytotoxic activity on human rhabdomyosarcoma (RD) epidermoid carcinoma (HEp-2) cell lines using the MTT method. Chemical profile determined HPLC-DAD, isolation studies were conducted. Results: found show concentration-dependent cytotoxicity against lines. In addition, comparison fraction previously isolated HPLC-DAD system, showed presence aucubin, amphicoside, veratroyl catalpol, veronicoside this fraction. On other hand, structure elucidation plantamajoside 4'-O-methylisoscutellarein-7-O-2''-O-(6'''-O-acetyl-ß-D-allopyranosyl)- ß-D-glucopyranoside from phenolic fractions performed serial chromatographic spectroscopic methods. Conclusion: To best our knowledge, first study titled plant. 8-hydroxyflavone glycosides important chemotaxonomy genus Veronica.